Ronymeran
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Mar 11, 2024
4:40 AM
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Are there any medications or substances that may interact with Sildigra 100 mg and prolong its effects?
Yes, several medications and substances may interact with Sildigra 100 mg (which contains Sildenafil citrate) and potentially prolong its effects. It's essential to be cautious when combining Sildigra with other medications or substances, as interactions can affect how Sildenafil is metabolized and cleared from the body. Here are some examples:
Nitrates: Combining Sildigra with nitrates, commonly prescribed for chest pain (angina), can lead to a severe drop in blood pressure. This interaction can increase the risk of hypotension (low blood pressure) and may lead to fainting or cardiovascular complications. Nitrates include medications such as nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate.
Alpha-Blockers: Alpha-blockers, used to treat high blood pressure and benign prostatic hyperplasia (BPH), can interact with Sildenafil and lead to symptomatic hypotension. Examples of alpha-blockers include doxazosin, prazosin, and terazosin.
Other PDE5 Inhibitors: Concurrent use of multiple PDE5 inhibitors, such as Sildenafil (Sildigra), Tadalafil, and Vardenafil, can increase the risk of adverse effects, including prolonged erection (priapism) and severe hypotension.
Grapefruit Juice: Grapefruit juice inhibits the enzyme responsible for metabolizing Sildenafil, potentially increasing blood levels of the medication and prolonging its effects. It's advisable to avoid consuming grapefruit or grapefruit juice while taking Sildigra.
Protease Inhibitors: Some medications used to treat HIV/AIDS, known as protease inhibitors, can increase blood levels of Sildenafil, leading to prolonged effects and an increased risk of side effects.
Certain Antibiotics: Antibiotics such as erythromycin and clarithromycin can inhibit the metabolism of Sildigra 100, leading to increased blood levels and potential prolongation of its effects.
Antifungal Medications: Azole antifungal medications like ketoconazole and itraconazole can inhibit the metabolism of Sildenafil, leading to increased blood levels and potentially prolonged effects.
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