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Kamagra 100 mg contains sildenafil citrate, which is a medication primarily used to treat erectile dysfunction (ED) in men. Sildenafil citrate belongs to a class of medications called phosphodiesterase type 5 (PDE5) inhibitors. The mode of action of Kamagra 100 mg involves several physiological processes in the body:
Inhibition of PDE5 enzyme: When a man is sexually stimulated, nitric oxide (NO) is released in the erectile tissue of the penis. Nitric oxide activates an enzyme called guanylate cyclase, which increases levels of cyclic guanosine monophosphate (cGMP). cGMP relaxes smooth muscles in the blood vessels of the penis, allowing them to dilate and increase blood flow, resulting in an erection. PDE5 enzyme breaks down cGMP, leading to the cessation of the erection. Sildenafil citrate in Kamagra 100 mg inhibits the action of PDE5 enzyme, allowing cGMP levels to remain elevated, which helps to prolong the duration of the erection.
Enhancement of nitric oxide pathway: Sildenafil citrate enhances the effects of nitric oxide by preventing its breakdown and promoting its activity. This leads to increased relaxation of smooth muscles and vasodilation (widening of blood vessels) in the penis, which facilitates the flow of blood necessary for achieving and maintaining an erection.
Specificity to penile tissue: While PDE5 inhibitors like sildenafil citrate are present throughout the body, their effects on blood vessels are more pronounced in the penile tissue due to the higher concentration of PDE5 enzyme in this area. This specificity helps to target the medication's action to the intended site of action, resulting in improved erectile function without significant effects on other parts of the body.
Overall, the mode of action of Kamagra 100 mg involves inhibition of PDE5 enzyme, enhancement of the nitric oxide pathway, and specificity to penile tissue, which collectively help to improve blood flow to the penis and facilitate the achievement and maintenance of erections during sexual stimulation.
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